Drug Discovery and Development, Volume 2.pdf

Drug Discovery and Development, Volume 2 PDF

From first principles to real-world applications-here is thefirst comprehensive guide to drug discovery and development

Modern drug discovery and development require the collaborativeefforts of specialists in a broadarray of scientific, technical,and business disciplines-from biochemistry to molecular biology,organic chemistry to medicinal chemistry, pharmacology tomarketing. Yet surprisingly, until now, there were no authoritativereferences offering a complete, fully integrated picture of theprocess.

The only comprehensive guide of its kind, this groundbreakingtwo-volume resource provides an overview of the entire sequence ofoperations involved in drug discovery and develop-?ment-frominitial conceptualization to commercialization to clinicians andmedical practitioners.

Volume 1: Drug Discovery describes all the steps in thediscovery process, including conceptualizing a drug, creating alibrary of candidates for testing, screening candidates for invitro and in vivo activity, conducting and analyzing the results ofclinical trials, and modifying a drug as necessary.

Volume 2: Drug Development delves into the nitty-grittydetails of optimizing the synthetic route, drug manufacturing,outsourcing, and marketing-including drug coloring and deliverymethods.

Featuring contributions from a world-class team of experts,Drug Discovery and Development:
* Features fascinating case studies, including the discovery anddevelopment of erythromycin analogs, Tagamet, and Ultiva(remifentanil)
* Discusses the discovery of medications for bacterialinfections, Parkinsons disease, psoriasis, peptic ulcers, atopicdermatitis, asthma, and cancer
* Includes chapters on combinatorial chemistry, molecularbiology-based drug discovery, genomics, and chemogenomics

Drug Discovery and Development is an indispensableworking resource for industrial chemists, biologists, biochemists,and executives who work in the pharmaceutical industry.

Volume 2: Discovering Lead Molecules. Virtual screening. Utility and applications of in vitro ADMET profiling in lead discovery. Retrometabolism-Based Drug ... The drug discovery process. Progress in Drug Research, Vol. 62. (Markus Rudin, Ed.) ... ery process. 2. The drug discovery (and development) phases: overview.

9780470085219 ISBN
Englisch SPRACHE
Drug Discovery and Development, Volume 2.pdf


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