Peptide Modifications to Increase Metabolic Stability and Activity.pdf

Peptide Modifications to Increase Metabolic Stability and Activity PDF

In Peptide Modifications to Increase Metabolic Stability and Activity, expert researchers in the field provide summarized methods for preparation, purification of modified peptides, and assessment of their biochemical activities. These methods and protocols include preparation of conformationally constrained peptides, modification of peptide bonds, introduction of nonproteinogenic amino acids, and alteration of peptides physical and biological properties by modification of the amino acid side chains and/or terminal residues. With additional chapter that describes new experimental approach for the detection of exogenous peptides within living cells using peptides labeled with heavy isotopes and confocal Raman microscopy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Peptide Modifications to Increase Metabolic Stability and Activity seeks to provide scientists with alternative approaches to peptide modification that many researchers may find applicable to their specific research requirements.

clinical trials.5,6 As a naturally occurring peptide, ADM provides explicit advantages for drug development, including high specificity and activity toward its target receptor. However, the low bioavailability and metabolic stability is a major drawback for the applicability of peptides as therapeutics, which Portfolio

7.85 MB DATEIGRÖSSE
1627036512 ISBN
Englisch SPRACHE
Peptide Modifications to Increase Metabolic Stability and Activity.pdf

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Sofia Voigt

Authoritative and practical, Peptide Modifications to Increase Metabolic Stability and Activity seeks to provide scientists with alternative approaches to peptide modification that many

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Matteo Müller

In Peptide Modifications to Increase Metabolic Stability and Activity, expert researchers in the field provide summarized methods for preparation, purification of modified peptides, and assessment of their biochemical activities. These methods and protocols include preparation of conformationally Peptide modifications to increase metabolic …

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Noel Schulze

19 Aug 2019 ... In many types of cancer, a significant increase in phosphatases has been observed. ... AuNPs was well correlated with the enzymatic activity (R2 = 0.994). ... The stability of pY peptide modified AuNPs. a Typical TEM image of ...

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Jason Lehmann

19 Aug 2019 ... In many types of cancer, a significant increase in phosphatases has been observed. ... AuNPs was well correlated with the enzymatic activity (R2 = 0.994). ... The stability of pY peptide modified AuNPs. a Typical TEM image of ...

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Jessica Kohmann

Exploring the human acetylome using high‐density peptide microarrays A playing a major role in regulating transcription, protein stability and activity of metabolic enzymes. Mass spectrometric investigations identified several thousand acceptor sites in human proteins. We created a peptide microarray displaying all known human lysine acetylation sites. Such peptide microarrays enable Improving Metabolic Stability By Glycosylation ...